AGN194204 (Synonyms: IRX4204; NRX194204; VTP 194204) |
| Catalog No.GC39584 |
AGN194204 (IRX4204) es un agonista selectivo y activo por vía oral de RXR con valores Kd de 0,4 nM, 3,6 nM y 3,8 nM y EC50s de 0,2 nM, 0,8 nM y 0.08 nM para RXRα, RXRβ y RXRγ respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 220619-73-8
Sample solution is provided at 25 µL, 10mM.
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AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 is inactive against RAR. AGN194204 has anti-inflammatory and anticarcinogenic actions[1][2].
[1]. Liby K, et al. A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland. Clin Cancer Res. 2007 Oct 15;13(20):6237-43. [2]. Vuligonda V, et al. Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. J Med Chem. 2001 Jul 5;44(14):2298-303.
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