Amylin |
| Catalog No.GC16513 |
La amilina, un polipéptido de 37 aminoÁcidos, es una hormona pancreÁtica secretada conjuntamente con la insulina que ejerce funciones Únicas en el metabolismo y la homeostasis de la glucosa.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 122384-88-7
Sample solution is provided at 25 µL, 10mM.
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Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent[1].
MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC50 of 35.2±7.5 nM[1].
Amylin, amide, human (400 μg peptide /kg body weight) is injected by subcutaneous route in separated groups of swiss male mice. A typical PK curve for the free amylin is observed, with a half-time of 23 min[1].
References:
[1]. Sisnande T, et al. Monoconjugation of Human Amylin with Methylpolyethyleneglycol. PLoS One. 2015 Oct 8;10(10):e0138803.
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