Amylin |
| Katalog-Nr.GC16513 |
Amylin, ein 37 AminosÄuren langes Polypeptid, ist ein zusammen mit Insulin sezerniertes Pankreashormon, das eine einzigartige Rolle im Stoffwechsel und in der GlukosehomÖostase spielt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 122384-88-7
Sample solution is provided at 25 µL, 10mM.
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Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent[1].
MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC50 of 35.2±7.5 nM[1].
Amylin, amide, human (400 μg peptide /kg body weight) is injected by subcutaneous route in separated groups of swiss male mice. A typical PK curve for the free amylin is observed, with a half-time of 23 min[1].
References:
[1]. Sisnande T, et al. Monoconjugation of Human Amylin with Methylpolyethyleneglycol. PLoS One. 2015 Oct 8;10(10):e0138803.
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