Amylin |
| Catalog No.GC16513 |
37개의 아미노산으로 구성된 폴리펩타이드인 아밀린은 신진대사와 포도당 항상성에 독특한 역할을 하는 인슐린과 함께 분비되는 췌장 호르몬입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 122384-88-7
Sample solution is provided at 25 µL, 10mM.
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Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent[1].
MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC50 of 35.2±7.5 nM[1].
Amylin, amide, human (400 μg peptide /kg body weight) is injected by subcutaneous route in separated groups of swiss male mice. A typical PK curve for the free amylin is observed, with a half-time of 23 min[1].
References:
[1]. Sisnande T, et al. Monoconjugation of Human Amylin with Methylpolyethyleneglycol. PLoS One. 2015 Oct 8;10(10):e0138803.
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