Avitinib (Synonyms: AC0010) |
| Catalog No.GC42884 |
Avitinib (AC0010) es un inhibidor de EGFR selectivo mutante e irreversible que inhibe eficazmente las mutaciones de resistencia de EGFR T790M en el cÁncer de pulmÓn de células no pequeÑas (NSCLC). Abivertinib también es un nuevo inhibidor de BTK.
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Cas No.: 1557267-42-1
Sample solution is provided at 25 µL, 10mM.
Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). It is selective for EGFR-active and T790M mutations, exhibiting a 298-fold increase in potency compared with wild-type EGFR. In a xenograft model, oral administration of 500 mg/kg avitinib was shown to result in complete remission of tumors with EGFR-active and T790M mutations.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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