GW9662
GW9662 exhibits half maximal inhibitory concentration (IC50) of 3.3 nM and is a well-characterized inhibitor of peroxisome proliferator-activated receptor gamma (PPARγ), demonstrating high selectivity for PPARy with the inhibitory activity greater for PPARγ about 10 to 600 times compared to PPARα and PPARδ in cellular environments.
Deferoxamine Mesylate
In the vast expanse of medical science, where each discovery is a step towards unraveling the mysteries of human health, Deferoxamine Mesylate emerges as a pivotal breakthrough in the realm of iron chelation therapy.
Brefeldin A
Cytotoxin Produced by diverse kinds of fungi e.g Paecilomyces sp. And Aspergillus clavatus isolated from Taxus mairei and Torreya grandis from Southeast china, 12,15-Dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one also called as Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor.
Mdivi 1
Mitochondrial division inhibitor-1 (Mdivi-1) ( mol.weight : 353.22, empirical formula: C15H10Cl2N2O2S) is a small chemical inhibitor of mitochondrial division dynamin, which plays multiple roles in mitochondrial dynamics, mitochondrial autophagy, ATP production, the immune response, and Ca²⁺ homeostasis.
RIPA Lysis Buffer (Strong)
RIPA Lysis Buffer is a traditional rapid lysis buffer for cellular tissues. It is a lysis and washing buffer that is used in reporter gene detection, protein kinase experiments, immunoassays, and protein purification.
BODIPY 493/503
BODIPY 493/503 (4,4-Difluoro-1,3,5,7,8-Pentamethyl-4-Bora-3a,4a-Diaza-SIndacene) usually employed for the quantification of neutral lipid content by utilizing flow cytometry and for the observation of lipid droplets by microscopy, is a fluorescent and a neutral lipid.
12-o-tetradecanoylphorbol-13-acetate (TPA, PMA)
Within the field of normal disquisition, certain mixes play a critical portion in unleashing the bigwig data of cellular forms and understanding complex common fabrics. Chemical mixes have continuously charmed experimenters with their one of a kind packages and empirical operations.
Cycloheximide
Produced by the bacterium Streptomyces griseus, Cycloheximide is a glutarimide antibiotic, occupying a unique space in the scientific tool box due to its antifungal properties and potential role in the inhibition of protein synthesis.
Phos-tag biotin BTL-104
A monobiotinylated Phos-tag derivative called BTL-104 is used to identify phosphopeptides and phosphoproteins. When the ligand molecule and biotin combine to form a functional conjugate (Phos-tag Biotin BTL-104), phosphorylated analytes on a PVDF membrane can be seen, making Phos-tagTM a potent tool.
Phos-tag Acrylamide
A useful chemical called Phos-tagTM is capable of capturing phosphorylated His/Asp/Lys and Ser/Thr/Tyr. It is a synthetic chemical molecule that was created using the catalytic domain of alkaline phosphatase as a model. Phos-tagged proteins can be separated, detected, analyzed using mass spectrometry, and purified using a range of procedures that use Phos-tagTM. An innovative and useful method for the enrichment and analysis of phosphorylated proteins is offered by phospho-tag acrylamide,