En números anteriores, presentamos diversas formulaciones y estrategias para la disolución de fármacos. Entre ellas, el DMSO, que no se recomienda, también tiene un lugar como co-disolvente, pero es bastante controvertido. El uso de este disolvente, restringido por la FDA, está ampliamente extendido y es altamente tóxico. ¿Qué tan tóxico es y cómo lo utilizamos en nuestros experimentos? Hoy revelaremos el uso correcto del "disolvente universal" DMSO en experimentos con células y animales.

Brent R. Stockwell, el autor que originó el concepto de ferroptosis, ha escrito una reseña sobre el progreso dela investigación en el 10.º aniversario dela ferroptosis, publicada en la revista Cell, conun alto factor de impacto de 66.85.

Introduction: RSM-932A, also known as TCD- 717, is a ChoKα asset, which targets the mortal choline kinase nascence, an enzyme involved in increased lipid metabolism of cancer cells. RSM-932A appears to have an altogether new medium of inhibition and is synergistic with respect to both choline and ATP. RSM-932A have in vitro inhibitory exertion in the low nanomolar range.

The sodium salt of palmitic acid, sodium palmitate ( Hexadecanoic acid sodium salt, Palmitic acid sodium salt) , produced during the process of fatty acid synthesis present in fats and waxes. It is produced synthetically and driven by palm oil. Plays major role as an emulsifier.

Brent R. Stockwell, the author of the origin of Ferroptosis, has written a review about research progress for the 10th anniversary of Ferroptosis, published in the journal Cell with a high impact factor of 66.85 (2022). The National Nature Foundation projects and the amount of money winning the bid in this direction are rising year by year, and the relevant research papers are also repeatedly topping the CNS! (Figure 1)

Existen varios modos de administración en estudios experimentales con animales, como la vía oral, intraperitoneal, intravenosa, inyección intracerebral, entre otros. Sin embargo, a menudo elegimos un método de administración de fármacos comúnmente utilizado en el laboratorio sin conocer la razón. Por ejemplo, en nuestro laboratorio se elige con frecuencia la inyección intraperitoneal, pero no se sabe por qué. De hecho, ¡hay mucho conocimiento incluido! En este caso, desde la perspectiva de la farmacología y la farmacocinética, se explicarán los principios para elegir el modo de administración.

Alisol B (ALB), a triterpenoid compound extracted from Alisma, has been reported to ameliorate nonalcoholic steatohepatitis (NASH) and slow obesity.

Semaglutide is a polypeptide composed of 31 amino acids related by peptide bonds, with a molecular heaviness of 4114 g/mol. It actions as an agonist for glucagon-like peptide-1 receptors (GLP-1 R) and is functioned in the action of type 2 diabetes. Semaglutide purposes as a hypoglycemic agent, a GLP-1 receptor agonist, an anti-obesity mediator, a neuroprotective mediator, and want for food suppressant.

20-Hydroxyeicosatetraenoic acid (20-HETE) manufactured by forward thinkers Glpbio having Molecular Formula: C20H32O3 and Molecular Weight: 320.5 g/mol , is a remarkable arachidonic acid metabolite, playing a key role in many physiological and pathological activities.It is a quantitative and analytical standard that is guaranteed to meet the MaxSpec identity, purity, stability and concentration specifications.

SP2509 also known as HCI-2509 is a small low molecular weight organic compound that can enter into cells and interact with the biological targets .It is used as research tool to study various diseases and biological processes including cancer , inflammation and neurological disorders .