BO-264 |
| Catalog No.GC39483 |
BO-264 es un inhibidor transformable acid-coil 3 (TACC3) muy potente y activo por vÍa oral con una IC50 de 188 nM y una Kd de 1,5 nM. BO-264 bloquea especÍficamente la funciÓn de la proteÍna de fusiÓn FGFR3-TACC3. BO-264 induce el paro mitÓtico dependiente del punto de control del ensamblaje del huso (SAC), el daÑo del ADN y la apoptosis. BO-264 tiene actividad antitumoral de amplio espectro.
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Cas No.: 2408648-20-2
Sample solution is provided at 25 µL, 10mM.
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BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity[1].
[1]. Akbulut O, et al. A Highly Potent TACC3 Inhibitor as a Novel Anti-cancer Drug Candidate. Mol Cancer Ther. 2020 Mar 26. pii: molcanther.0957.2019.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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