BO-264 |
| Catalog No.GC39483 |
BO-264는 IC50이 188nM이고 Kd가 1.5nM인 매우 강력한 경구 활성 변형 산성 코일 코일 3(TACC3) 억제제입니다. BO-264는 FGFR3-TACC3 융합 단백질의 기능을 특이적으로 차단합니다. BO-264는 SAC(spindle assembly checkpoint) 의존적 유사분열 정지, DNA 손상 및 세포자멸사를 유도합니다. BO-264는 광범위한 항종양 활성을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2408648-20-2
Sample solution is provided at 25 µL, 10mM.
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BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity[1].
[1]. Akbulut O, et al. A Highly Potent TACC3 Inhibitor as a Novel Anti-cancer Drug Candidate. Mol Cancer Ther. 2020 Mar 26. pii: molcanther.0957.2019.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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