BO-264 |
| Catalog No.GC39483 |
Le BO-264 est un inhibiteur de coiled-coil 3 (TACC3) hautement puissant et actif par voie orale avec une IC50 de 188 nM et un Kd de 1,5 nM. BO-264 bloque spécifiquement la fonction de la protéine de fusion FGFR3-TACC3. Le BO-264 induit un arrêt mitotique dépendant du point de contrÔle de l'assemblage du fuseau (SAC), des dommages À l'ADN et l'apoptose. BO-264 a une activité antitumorale À large spectre.
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Cas No.: 2408648-20-2
Sample solution is provided at 25 µL, 10mM.
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BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity[1].
[1]. Akbulut O, et al. A Highly Potent TACC3 Inhibitor as a Novel Anti-cancer Drug Candidate. Mol Cancer Ther. 2020 Mar 26. pii: molcanther.0957.2019.
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