BS 181 dihydrochloride |
| Catalog No.GC50217 |
El diclorhidrato de BS 181 es un inhibidor potente y selectivo de CDK7 (IC50 \u003d 21 nM) que Seliciclib. BS-181 también es contra CDK2, CDK5 y CDK9 con valores IC50 de 880 nM, 3000 nM y 4200 nM, respectivamente (no bloquea CDK1, 4 y 6). El diclorhidrato de BS 181 inhibe el crecimiento de un panel de células cancerosas (IC50\u003d11,5 μM-37,3 μM) e induce la apoptosis celular. El diclorhidrato de BS 181 tiene el potencial para la investigación de la terapia del cáncer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883548-83-1
Sample solution is provided at 25 µL, 10mM.
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Selective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over others cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.
Ali et al (2009) The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69 6208 PMID:19638587
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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