BS 181 dihydrochloride |
| Catalog No.GC50217 |
El diclorhidrato de BS 181 es un inhibidor potente y selectivo de CDK7 (IC50 \u003d 21 nM) que Seliciclib. BS-181 también es contra CDK2, CDK5 y CDK9 con valores IC50 de 880 nM, 3000 nM y 4200 nM, respectivamente (no bloquea CDK1, 4 y 6). El diclorhidrato de BS 181 inhibe el crecimiento de un panel de células cancerosas (IC50\u003d11,5 μM-37,3 μM) e induce la apoptosis celular. El diclorhidrato de BS 181 tiene el potencial para la investigación de la terapia del cáncer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883548-83-1
Sample solution is provided at 25 µL, 10mM.
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Selective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over others cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.
Ali et al (2009) The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69 6208 PMID:19638587
| Cas No. | 1883548-83-1 | SDF | |
| Canonical SMILES | CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1.Cl.Cl | ||
| Formula | C22H32N6.2HCl | M.Wt | 453.45 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2053 mL | 11.0266 mL | 22.0531 mL |
| 5 mM | 0.4411 mL | 2.2053 mL | 4.4106 mL |
| 10 mM | 0.2205 mL | 1.1027 mL | 2.2053 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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