Sodium 4-Phenylbutyrate-d11 (Synonyms: Benzenebutanoic acid-d11, TriButyrate-d11) |
Catalog No.GC48084 |
El fenilbutirato-d11 (sodio) es 4-fenilbutirato de sodio marcado con deuterio. El 4-fenilbutirato de sodio (4-PBA de sodio) es un inhibidor de la HDAC y el estrés del retÍculo endoplÁsmico (ER), que se utiliza en la investigaciÓn del cÁncer y las infecciones.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1392208-11-5
Sample solution is provided at 25 µL, 10mM.
Sodium 4-Phenylbutyrate-d11 is intended for use as an internal standard for the quantification of sodium 4-phenylbutyrate by GC- or LC-MS. Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.1,2 It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.3,4 Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.
1.Stewart, G.A., Ridscale, R., Martin, E.P., et al.4-Phenylbutyric acid treatment rescues trafficking and processing of a mutant surfactant protein-CAmerican Journal of Respiration, Cell, and Molecular Biology47(3)324-331(2012) 2.Bradbury, N.A.Focus on "sodium 4-phenylbutyrate downregulates Hsc70: Implications for intracellular trafficking of δF508-CFTR"Am. J. Physiol. Cell Physiol.278(2)C257-C258(2000) 3.Lu, Q., Wang, D.S., Chen, C.S., et al.Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitorsJ. Med. Chem.48(17)5530-5535(2005) 4.Ammerpohl, O., Trauzold, A., Schniewind, B., et al.Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cellsBr. J. Cancer96(1)73-81(2007)
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(Based on Reviews and 6 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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