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CN128 (Synonyms: R-CN128)

Catalog No.GC60719

CN128 (CN328) es un quelante de hierro selectivo y activo por vÍa oral.

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CN128 Chemical Structure

Cas No.: 1335282-05-7

Tamaño Precio Disponibilidad Cantidad
5mg
185,00 $
Disponible
10mg
278,00 $
Disponible
50mg
788,00 $
Disponible
100mg
1.159,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

CN128 is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1].

CN128 possesses a high selectivity for iron(III) over others metals[1].

CN128 (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat[1].The iron removal efficacies of CN128 displays a dose-dependent behavior[1].CN128 lacks genetic toxicity[1].CN128 (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].CN128 is well-tolerated, with no mortality being observed at the higher dose levels in rats[1]. Animal Model: Male SD rats (300 g)[1]

[1]. Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226.

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