CN128 (Synonyms: R-CN128) |
| Catalog No.GC60719 |
CN128 (CN328) est un chélateur de fer actif et sélectif par voie orale.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1335282-05-7
Sample solution is provided at 25 µL, 10mM.
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CN128 is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1].
CN128 possesses a high selectivity for iron(III) over others metals[1].
CN128 (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat[1].The iron removal efficacies of CN128 displays a dose-dependent behavior[1].CN128 lacks genetic toxicity[1].CN128 (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].CN128 is well-tolerated, with no mortality being observed at the higher dose levels in rats[1]. Animal Model: Male SD rats (300 g)[1]
[1]. Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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