Mycophenolate Mofetil-d4 (Synonyms: MMF-d4) |
| Catalog No.GC47712 |
El micofenolato de mofetilo-d4 es el micofenolato de mofetilo etiquetado con deuterio. El micofenolato de mofetilo (RS 61443) es el profÁrmaco morfolinoetiléster del Ácido micofenÓlico. El micofenolato de mofetilo inhibe la sÍntesis de purinas de novo a través de la inhibiciÓn de la inosina monofosfato deshidrogenasa (IMPDH). El micofenolato de mofetilo muestra efectos antiproliferativos selectivos de linfocitos que involucran tanto a las células T como a las B, lo que previene la formaciÓn de anticuerpos.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1132748-21-0
Sample solution is provided at 25 µL, 10mM.
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Mycophenolate mofetil-d4 is intended for use as an internal standard for the quantification of mycophenolate mofetil by GC- or LC-MS. Mycophenolate mofetil is a prodrug form of mycophenolic acid .1,2,3 In vivo, mycophenolate mofetil (12.5 mg/kg) increases duration of transplant motor activity in a rabbit model of retroperitoneal heterotopic heart transplantation.1 It eliminates formation of microbleeds and hemorrhages in the cerebrum of stroke-prone spontaneously hypertensive rats.2 Mycophenolate mofetil also lowers mean arterial pressure (MAP) and reduces urinary albumin excretion and glomerulosclerosis, markers of renal damage, in a mouse model of systemic lupus erythematosus (SLE).3
1.AygÜn, F., Efe, D., and Durgut, K.Comparison of MMF with prednisone in terms of rejection and duration of activity of transplant in rabbits that underwent retroperitoneal heterotopic heart transplantationCardiovasc. J. Afr.26(3)104-108(2015) 2.Dhande, I.S., Zhu, Y., Braun, M.C., et al.Mycophenolate mofetil prevents cerebrovascular injury in stroke-prone spontaneously hypertensive ratsPhysiol. Genomics49(3)132-140(2017) 3.Taylor, E.B., and Ryan, M.J.Immunosuppression with mycophenolate mofetil attenuates hypertension in an experimental model of autoimmune diseaseJ. Am. Heart Assoc.6(3)e005394(2017)
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