Itacitinib (Synonyms: INCB 039110) |
| Catalog No.GC19204 |
Itacitinib (INCB039110) es un inhibidor selectivo y activo por vÍa oral de JAK1 con una IC50 de 2 nM para JAK1 humano. Itacitinib muestra una selectividad >20 veces para JAK1 sobre JAK2 y >100 veces para JAK3 y TYK2; Itacitinib se utiliza en la investigaciÓn de la mielofibrosis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1334298-90-6
Sample solution is provided at 25 µL, 10mM.
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Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis.
Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis[1].
References:
[1]. Mascarenhas JO, et al. Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis. Haematologica. 2017 Feb;102(2):327-335.
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