TAN 1364B (Synonyms: RK-682 (rac-1)) |
| Catalog No.GC41443 |
TAN 1364B, un racemato de RK-682, es un inhibidor de las proteÍnas tirosina fosfatasas (PTPasas). TAN 1364B inhibe la proteÍna tirosina fosfatasa 1B (PTP-1B), las proteÍnas tirosina fosfatasas de bajo peso molecular (LMW-PTP) y el ciclo de divisiÓn celular 25B (CDC-25B) con IC50 de 8,6 μM, 12,4 μM y 0,7 μM, respectivamente.
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Cas No.: 154639-24-4
Sample solution is provided at 25 µL, 10mM.
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TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 . TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 µM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.
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