7,4'-Dihydroxyflavone (Synonyms: 7,4'-DHF) |
| Catalog No.GC35185 |
La 7,4'-dihidroxiflavona (7,4'-DHF) es un flavonoide aislado de Glycyrrhiza uralensis, el inhibidor de eotaxina/CCL11, tiene la capacidad de suprimir constantemente la producciÓn de eotaxina y prevenir los efectos adversos paradÓjicos de la dexametasona (Dex) sobre la producciÓn de eotaxina. 1].
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2196-14-7
Sample solution is provided at 25 µL, 10mM.
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7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1]. IC50: 1.4 μM (NCI-H292 human airway epithelial cell) (7,4'-Dihydroxyflavone)[2]
[1]. Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts. Phytother Res. 2017 Mar;31(3):449-458. [2]. Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2. Phytother Res. 2015 Jun;29(6):925-32.
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