CTPI-2 |
| Catalog No.GC19138 |
CTPI-2 es un inhibidor de SLC25A1 portador de citrato mitocondrial de tercera generaciÓn con una KD de 3,5 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 68003-38-3
Sample solution is provided at 25 µL, 10mM.
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CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo; disrupts self-renewal and sphere-forming capacity of the indicated tumor cells relative to monolayer cultures, demonstrates broad activity on lung CSCs, inhibiting mitochondrial respiratory activity, self-renewal and matrix invasion; inhibits tumor growth in in vivo models of NSCLC.
Reference:
[1]. Fernandez HR, et al. Cell Death Differ. 2018 Jul;25(7):1239-1258.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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