DEPMPO (Synonyms: 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide) |
| Catalog No.GC43410 |
cDEPMPO es un potente profÁrmaco contra el cÁncer. Las altas concentraciones de DEPMPO atrapan por rotaciÓn el radical .OH junto con los radicales arilo que surgen de compuestos BTO (benzotriazina 1,4-di-N-Óxido) reducidos con un electrÓn.
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Cas No.: 157230-67-6
Sample solution is provided at 25 µL, 10mM.
DEPMPO is a phosphorylated derivative of the widely used DMPO spin trap. It has been reported to produce spin adducts with increased stability particularly for the adduct of superoxide. [1] [2] [3] DEPMPO displays a detectable spin adduct signal at a concentration as low as 1 mM, as compared to 5 mM for DMPO.[3] A significant advantage of using DEPMPO in trapping superoxide radical is that the decomposition of DEPMPO/O2•- does not produce the OH• adduct, which can be a drawback when using DMPO. [2][3]
Reference:
[1]. Khan, N., Wilmont, C.M., Rosen, G.M., et al. Spin traps: In vitro toxicity and stability of radical adducts. Free Radical Biology & Medicine 34(11), 1473-1481 (2003).
[2]. Anzai, K., Aikawa, T., Furukawa, Y., et al. ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes. Archives of Biochemistry and Biophysics 415, 251-256 (2003).
[3]. Liu, K.J., Miyake, M., Panz, T., et al. Evaluation of DEPMPO as a spin trapping agent in biological systems. Free Radical Biology & Medicine 26, 714-721 (1999).
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