DEPMPO (Synonyms: 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide) |
| カタログ番号GC43410 |
cDEPMPO は、強力な抗がん剤のプロドラッグです。高濃度の DEPMPO は、一電子還元 BTO (ベンゾトリアジン 1,4-ジ-N-オキシド) 化合物から生じるアリールラジカルと共に .OH ラジカルをスピントラップします。
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Cas No.: 157230-67-6
Sample solution is provided at 25 µL, 10mM.
DEPMPO is a phosphorylated derivative of the widely used DMPO spin trap. It has been reported to produce spin adducts with increased stability particularly for the adduct of superoxide. [1] [2] [3] DEPMPO displays a detectable spin adduct signal at a concentration as low as 1 mM, as compared to 5 mM for DMPO.[3] A significant advantage of using DEPMPO in trapping superoxide radical is that the decomposition of DEPMPO/O2•- does not produce the OH• adduct, which can be a drawback when using DMPO. [2][3]
Reference:
[1]. Khan, N., Wilmont, C.M., Rosen, G.M., et al. Spin traps: In vitro toxicity and stability of radical adducts. Free Radical Biology & Medicine 34(11), 1473-1481 (2003).
[2]. Anzai, K., Aikawa, T., Furukawa, Y., et al. ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes. Archives of Biochemistry and Biophysics 415, 251-256 (2003).
[3]. Liu, K.J., Miyake, M., Panz, T., et al. Evaluation of DEPMPO as a spin trapping agent in biological systems. Free Radical Biology & Medicine 26, 714-721 (1999).
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