Epiblastin A |
| Catalog No.GC43618 |
La epiblastina A es un inhibidor competitivo de ATP de la caseÍna quinasa 1 (CK1) con IC50 de 8,9, 0,5 y 4,7 μM para CK1α, CK1δ y CK1 ɛ, respectivamente. La epiblastina A induce la reprogramaciÓn de las células madre del epiblasto en células madre embrionarias mediante la inhibiciÓn de CK1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 16470-02-3
Sample solution is provided at 25 µL, 10mM.
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Epiblastin A is an ATP-competitive inhibitor of the casein kinase 1 (CK1) isoforms α, δ, and ε (IC50s = 8.9, 0.5, and 4.7 μM, respectively). [1] It is selective for CK1α, CK1δ, and CK1ε at concentrations below 10 μM, however, it also inhibits BRSK1, EEF2K, EGFR, MNK-2, and RIPK2 (IC50s = 24-45 μM). Epiblastan A reduces immunoprecipitation of CK1α, CK1δ, and CK1ε from HCT116 cell lysates in a concentration-dependent manner. It induces reprogramming of mouse epiblast stem cells (mEpiSCs) into embryonic stem cells (ESCs) 8-fold more efficiently than triamterene .
Reference:
[1]. Ursu, A., Illich, D.J., Takemoto, Y., et al. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of Casein Kinase 1. Cell Chem. Biol. 23(4), 494-507 (2016).
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