ERK1/2 inhibitor 1 |
| Catalog No.GC65510 |
El inhibidor 1 de ERK1/2 es un potente inhibidor de ERK1/2 biodisponible por vÍa oral, que muestra una inhibiciÓn del 60 % a 1 nM y una IC50 de 3,0 nM contra ERK1 y ERK2, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2095719-90-5
Sample solution is provided at 25 µL, 10mM.
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ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1].
ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1].
[1]. Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61(11):4978-4992.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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