ERK1/2 inhibitor 1 |
| Katalog-Nr.GC65510 |
ERK1/2-Inhibitor 1 ist ein potenter, oral bioverfÜgbarer ERK1/2-Inhibitor, der eine 60%ige Hemmung bei 1 nM und einen IC50 von 3,0 nM gegen ERK1 bzw. ERK2 zeigt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2095719-90-5
Sample solution is provided at 25 µL, 10mM.
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ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1].
ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1].
[1]. Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61(11):4978-4992.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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