Ezetimibe ketone |
| Catalog No.GC60159 |
La cetona de ezetimiba (EZM-K) es un metabolito de fase I de la ezetimiba.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 191330-56-0
Sample solution is provided at 25 µL, 10mM.
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Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor[1][2][3].
[1]. Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. Synthetic Communications. 2016, 46:20, 1687-1693. [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [3]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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