Flavokawain B |
| Catalog No.GC41261 |
Flavokawain B (Flavokavain B) es una chalcona aislada de los extractos de raÍz de la planta kava-kava y un potente inductor de apoptosis para inhibir el crecimiento de varias lÍneas de células cancerosas. Flavokawain B (Flavokavain B) muestra una fuerte actividad antiangiogénica. Flavokawain B (Flavokavain B) inhibe la migraciÓn de células endoteliales del cerebro humano (HUVEC) y la formaciÓn de tubos con concentraciones muy bajas y no tÓxicas.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1775-97-9
Sample solution is provided at 25 µL, 10mM.
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Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 µM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim. Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice. It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells. However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-κB signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD50s = 15 and 32 µM, respectively).
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