FT-1518 |
| Catalog No.GC33355 |
FT-1518 es un inhibidor de mTORC1 y mTORC2 selectivo, potente y biodisponible por vÍa oral de nueva generaciÓn, y exhibe actividad antitumoral.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1313026-58-2
Sample solution is provided at 25 µL, 10mM.
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FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity.
FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. FT-1518 displays significant growth inhibitory activity against a large panel of hematologic and solid tumor cell lines with most activities falling into low nanomolar range. FT-1518 cuases potent inhibition of the mTOR pathway biomarkers (mTORC 1 & 2 biomarkers [pAkt(S473) and pS6(S240/244) or p70 S6K), no inhibition of PI3K biomarker [pAkt(T308)] in cells[1].
FT-1518 exhibits dose-dependent and higher tumor growth inhibition (TGI) in multiple solid tumor xenografts[1].
[1]. Alain C. Mita, et al. Abstract 137: FT-1518, a new generation selective and potent mTORC1 and mTORC2 inhibitor: an in vitro and in vivo profile. Cancer Res 2017;77(13 Suppl).
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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