Fumarate hydratase-IN-2 sodium salt |
| Catalog No.GC34383 |
La sal sÓdica de fumarato hidratasa-IN-2 (compuesto 3) es un inhibidor competitivo y permeable a las células de la fumarato hidratasa (Ki = 4,5 μM) con citotoxicidad dependiente de nutrientes.
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Sample solution is provided at 25 µL, 10mM.
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.Fumarate hydratase is an enzyme of the TCA cycle and cell-permeable inhibitors (1) inhibition of fumarate hydratase can contribute to tumorigenicity in some cells. (2) The use of a photoaffinity labeling strategy identified fumarate hydratase as the principal pharmacological target. Final biochemical studies confirmed dose-dependent, competitive inhibition of this enzyme (3) Chemical inhibition of fumarate hydratase renders cells highly dependent on glucose metabolism for survival.
[1]. Takeuchi T et al. Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity. J Am Chem Soc. 2015 Jan 21;137(2):564-7.
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