Aminomalonic acid |
Catalog No.GC35321 |
El Ácido aminomalÓnico es un metabolito endÓgeno amino, actÚa como un fuerte inhibidor de la L-asparagina sintetasa de la leucemia 5178Y/AR (Ki= 0,0023 M) y pÁncreas de ratÓn (Ki= 0,0015 M) in vitro. El Ácido aminomalÓnico es un biomarcador potencial para discriminar entre diferentes etapas de metÁstasis de melanoma.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1068-84-4
Sample solution is provided at 25 µL, 10mM.
Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis[1][2][3]. Ki: 0.0023 M (L-asparagine synthetase from Leukemia 5178Y/AR), 0.0015 M (L-asparagine synthetase from mouse pancreas)[2]
[1]. Van Buskirk JJ, et al. Aminomalonic acid: identification in Escherichia coli and atherosclerotic plaque. Proc Natl Acad Sci U S A. 1984 Feb;81(3):722-5. [2]. Milman HA, et al. Aminomalonic acid and its congeners as potential in vivo inhibitors of L-asparagine synthetase. Enzyme. 1979;24(1):36-47. [3]. Kim HY, et al. Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling. Sci Rep. 2017 Aug 18;7(1):8864.
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