Aminomalonic acid |
| カタログ番号GC35321 |
アミノマロン酸はアミノ内因性代謝産物であり、in vitro で白血病 5178Y/AR (Ki= 0.0023 M) およびマウス膵臓 (Ki= 0.0015 M) からの L-アスパラギン合成酵素の強力な阻害剤として作用します。アミノマロン酸は、メラノーマ転移の異なる段階を識別する潜在的なバイオマーカーです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1068-84-4
Sample solution is provided at 25 µL, 10mM.
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Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis[1][2][3]. Ki: 0.0023 M (L-asparagine synthetase from Leukemia 5178Y/AR), 0.0015 M (L-asparagine synthetase from mouse pancreas)[2]
[1]. Van Buskirk JJ, et al. Aminomalonic acid: identification in Escherichia coli and atherosclerotic plaque. Proc Natl Acad Sci U S A. 1984 Feb;81(3):722-5. [2]. Milman HA, et al. Aminomalonic acid and its congeners as potential in vivo inhibitors of L-asparagine synthetase. Enzyme. 1979;24(1):36-47. [3]. Kim HY, et al. Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling. Sci Rep. 2017 Aug 18;7(1):8864.
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