E3 ligase Ligand-Linker Conjugates 30 |
| Catalog No.GC35935 |
E3 ligase Ligand-Linker Conjugates 30 es un conjugado de ligando-enlazador de E3 ligasa sintetizado que incorpora el ligando cereblon basado en pomalidomida y el conector PEG de 3 unidades utilizado en la tecnologÍa PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2093416-31-8
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC degrader[1]. Cereblon
[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466.
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