FMF-04-159-2 |
| Catalog No.GC36062 |
FMF-04-159-2 es un inhibidor covalente de CDK14. FMF-04-159-2 inhibe CDK14 y CDK2 con IC50 de 39,6 nM y 256 nM en el ensayo NanoBRET, respectivamente.
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Cas No.: 2364489-81-4
Sample solution is provided at 25 µL, 10mM.
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FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively[1]. CDK14/Cyclin Y|39.6 nM (IC50, in NanoBRET assay)|CDK2|256 nM (IC50, in NanoBRET assay)
FMF-04-159-2 inhibits HCT116 proliferation with an IC50 of 1,144±190 nM[1].
[1]. Ferguson FM, et al. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4.
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