Quilseconazole (Synonyms: VT-1129) |
| Catalog No.GC37061 |
El quilseconazol (VT-1129) es un potente inhibidor fÚngico de Cyp51 (lanosterol 14-α-desmetilasa), activo por vÍa oral, que se une estrechamente al criptococo CYP51, pero inhibe débilmente las enzimas CYP450 humanas.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1340593-70-5
Sample solution is provided at 25 µL, 10mM.
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Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes[1]. Fungal, Cyp51[1]
[1]. Lockhart SR, et al. The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2528-31.
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