RU-SKI 43 |
| Catalog No.GC37573 |
RU-SKI 43 es un inhibidor potente y selectivo de Hedgehog aciltransferasa (Hhat) con una IC50 de 850 nM. RU-SKI 43 reduce la activaciÓn de Gli-1 a través de la seÑalizaciÓn no canÓnica independiente de Smoothened y disminuye la actividad de las vÍas Akt y mTOR. RU-SKI 43 tiene actividad anticancerÍgena.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1043797-53-0
Sample solution is provided at 25 µL, 10mM.
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RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.IC50 value:Target: Hhat inhibitorRU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.
[1]. Petrova E, et al. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.575.
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