RU-SKI 43 |
Katalog-Nr.GC37573 |
RU-SKI 43 ist ein potenter und selektiver Hemmer der Hedgehog-Acyltransferase (Hhat) mit einem IC50-Wert von 850 nM. RU-SKI 43 reduziert die Gli-1-Aktivierung durch Smoothened-unabhÄngige nicht-kanonische SignalÜbertragung und verringert die AktivitÄt des Akt- und mTOR-Signalwegs. RU-SKI 43 hat Anti-Krebs-AktivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1043797-53-0
Sample solution is provided at 25 µL, 10mM.
RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.IC50 value:Target: Hhat inhibitorRU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.
[1]. Petrova E, et al. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.575.
Average Rating: 5
(Based on Reviews and 10 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *