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Tubulysin

Catalog No.GC37835

La familia de metabolitos secundarios de la tubulisina se aislÓ originalmente de las mixobacterias Archangium geophyra y Angiococcus disciformis. Estos compuestos son potentes agentes desestabilizadores de microtÚbulos con valores IC50 en el rango picomolar contra muchas lÍneas de células cancerosas, incluidas aquellas con propiedades resistentes a mÚltiples fÁrmacos. Las tubulisinas tienen una utilidad terapéutica limitada debido a su toxicidad grave, por lo que las tubulisinas son candidatas ideales para incorporarlas en el sistema de administraciÓn de conjugados de fÁrmacos moleculares (SMDC).

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Tubulysin Chemical Structure

Cas No.: 1943604-24-7

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system[1].

[1]. Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813.

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Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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