Tubulysin |
| Katalog-Nr.GC37835 |
Die Tubulysin-Familie von SekundÄrmetaboliten wird ursprÜnglich aus den Myxobakterien Arrangium geophyra und Angiococcus disciformis isoliert. Diese Verbindungen sind wirksame Mittel zur Destabilisierung von Mikrotubuli mit IC50-Werten im pikomolaren Bereich gegen viele Krebszelllinien, einschließlich solcher mit multiresistenten Eigenschaften. Tubulysine haben aufgrund ihrer starken ToxizitÄt einen begrenzten therapeutischen Nutzen, daher sind Tubulysine ideale Kandidaten, um in ein Abgabesystem fÜr MolekÜl-Wirkstoff-Konjugate (SMDC) eingebaut zu werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1943604-24-7
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system[1].
[1]. Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *