Gartanin (Synonyms: NSC 692946) |
| Catalog No.GC38087 |
La gartanina es una xantona natural del mangostÁn, con propiedades antioxidantes, antiinflamatorias, antifÚngicas, neuroprotectoras y antineoplÁsicas. Gartanin induce la detenciÓn del ciclo celular y la autofagia y suprime la migraciÓn en células de glioma humano.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 33390-42-0
Sample solution is provided at 25 µL, 10mM.
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Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells[1][2].
Gartanin is a potential agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α signaling pathways [1].Gartanin induces cell cycle arrest and autophagy and suppresses migration involving PI3K/Akt/mTOR and MAPK signalling pathway in human glioma cells [1].
[1]. Gao XY, et al. Gartanin Protects Neurons against Glutamate-Induced Cell Death in HT22 Cells: Independence of Nrf-2 but Involvement of HO-1 and AMPK. Neurochem Res. 2016 Sep;41(9):2267-77. [2]. Kim MO, et al. Gartanin induces autophagy through JNK activation which extenuates caspase-dependent apoptosis. Oncol Rep. 2015 Jul;34(1):139-46.
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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