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AGX51

Catalog No.GC38590

AGX51 es un antagonista y degradador pan-Id (inhibidores de proteÍnas de uniÓn/diferenciaciÓn de ADN) de primera clase. AGX51 inhibe la interacciÓn Id1-E47, lo que conduce a la degradaciÓn de Ids mediada por ubiquitina, la detenciÓn del crecimiento celular y reduce la viabilidad. AGX51 inhibe las lÍneas celulares TNBC con IC50 de casi 25 μM. AGX51 se puede utilizar para la investigaciÓn del cÁncer.

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AGX51 Chemical Structure

Cas No.: 330834-54-3

Tamaño Precio Disponibilidad Cantidad
1mg
86,00 $
Disponible
5mg
252,00 $
Disponible
10mg
396,00 $
Disponible
25mg
713,00 $
Disponible
50mg
1.188,00 $
Disponible
100mg
1.620,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

AGX51 is a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader. AGX51 inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability. AGX51 inhibits pathologic ocular neovascularization[1].

[1]. Wojnarowicz PM, et al. A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 Oct 1;29(1):62-75.e7.

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Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

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