AGX51 |
| Catalog No.GC38590 |
AGX51은 동급 최초의 pan-Id(DNA 결합/분화 단백질 억제제) 길항제 및 분해제입니다. AGX51은 Id1-E47 상호작용을 억제하여 Ids의 유비퀴틴 매개 분해, 세포 성장 정지 및 생존력 감소를 유발합니다. AGX51은 거의 25μM의 IC50으로 TNBC 세포주를 억제합니다. AGX51은 암 연구에 사용될 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 330834-54-3
Sample solution is provided at 25 µL, 10mM.
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AGX51 is a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader. AGX51 inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability. AGX51 inhibits pathologic ocular neovascularization[1].
[1]. Wojnarowicz PM, et al. A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 Oct 1;29(1):62-75.e7.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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