AGX51 |
カタログ番号GC38590 |
AGX51 は、クラス初の pan-Id (DNA 結合/分化タンパク質の阻害剤) のアンタゴニストおよびデグレーダーです。 AGX51 は Id1-E47 相互作用を阻害し、ユビキチンを介した Id の分解、細胞増殖の停止、生存率の低下を引き起こします。 AGX51 は、ほぼ 25 μM の IC50 で TNBC 細胞株を阻害します。 AGX51はがんの研究に使用できます。
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Cas No.: 330834-54-3
Sample solution is provided at 25 µL, 10mM.
AGX51 is a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader. AGX51 inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability. AGX51 inhibits pathologic ocular neovascularization[1].
[1]. Wojnarowicz PM, et al. A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 Oct 1;29(1):62-75.e7.
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