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2',3',5'-Triacetyluridine

Catalog No.GC45321

 

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2',3',5'-Triacetyluridine Chemical Structure

Cas No.: 4105-38-8

Tamaño Precio Disponibilidad Cantidad
5g
43,00 $
Disponible
10g
82,00 $
Disponible
25g
194,00 $
Disponible
50g
258,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description of 2',3',5'-Triacetyluridine

2',3',5'-Triacetyluridine is a prodrug of uridine .1 It is more lipid soluble than uridine and resistant to degradation by uridine phosphorylase. It is cleaved by plasma esterases in vivo to release uridine. 2',3',5'-Triacetyluridine (6% in the diet) decreases neurodegeneration in the piriform cortex and striatum, as well as reduces the amount of huntingtin-positive aggregates and increases BDNF protein levels in the piriform cortex in a transgenic mouse model of Huntington's disease.2 It also improves rotarod performance and increases survival in transgenic mouse models of Huntington's disease. 2',3',5'-Triacetyluridine reverses toxicity and increases survival in a mouse model of dihydropyrimidine dehydrogenase (DPD) deficiency-induced 5-fluorouracil overdose when used at a concentration of 2,000 mg/kg three times per day beginning within 24 hours of 5-FU administration.3 Formulations containing 2',3',5'-triacetyluridine have been used in the treatment of hereditary orotic aciduria and of overdose or life-threatening toxicity due to flurouracil or capecitabine.

References
1. Ashour, O.M., Naguib, F.N.M., and el Kouni, M.H. 5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration: Implications for chemotherapy. Biochem. Pharmacol. 51(12), 1601-1611 (1996).
2. Saydoff, J.A., Garcia, R.A.G., Browne, S.E., et al. Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease. Neurobiol. Dis. 24(3), 455-465 (2006).
3. von Borstel, R.W., O'Neil, J.D., Saydoff, J.A., et al. Uridine triacetate for lethal 5-FU toxicity due to dihydropyrimidine dehydrogenase (DPD) deficiency. J. Clin. Oncol. 28(15_supp), e13505-e13505 (2010).

Chemical Properties of 2',3',5'-Triacetyluridine

Cas No. 4105-38-8 SDF
Canonical SMILES O=C(NC(C=C1)=O)N1[C@H]2[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O2
Formula C15H18N2O9 M.Wt 370.3
Solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 2',3',5'-Triacetyluridine

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.7005 mL 13.5026 mL 27.0051 mL
5 mM 0.5401 mL 2.7005 mL 5.401 mL
10 mM 0.2701 mL 1.3503 mL 2.7005 mL
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In vivo Formulation Calculator (Clear solution) of 2',3',5'-Triacetyluridine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 17 reference(s) in Google Scholar.)

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