GDC-0927 (SRN-927) (Synonyms: SRN-927) |
| Catalog No.GC32920 |
GDC-0927 (SRN-927) (SRN-927) es un potente antagonista selectivo de los receptores de estrÓgeno, no esteroideo, biodisponible por vÍa oral.
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Cas No.: 1642297-01-5
Sample solution is provided at 25 µL, 10mM.
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GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist.
GDC-0927 is a novel, potent, non-steroidal, orally bioavailable, selective ER antagonist/ER degrader (SERD) that induces tumor regression in estrogen receptor (ER)+breast cancer (BC) patient-derived xenograft models[1].
[1]. MN Dickler, et al. Abstract PD5-10: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-0927, in postmenopausal women with estrogen receptor positive (ER+) HER2-negative metastatic breast cancer (BC). AACR; Cancer Res 2018;78(4 Suppl):Abstract nr PD5-10.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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