Gemfibrozil 1-O-β-Glucuronide |
| Catalog No.GC43743 |
Gemfibrozil 1-O-β-Glucuronide, un metabolito de Gemfibrozil, es un inhibidor potente y competitivo de la isoforma CYP2C8 de P450 (CYP) con una IC50 de 4,07 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 91683-38-4
Sample solution is provided at 25 µL, 10mM.
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Gemfibrozil 1-O-β-glucuronide is a major metabolite of gemfibrozil that is formed when gemfibrozil undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7. Gemfibrozil 1-O-β-glucuronide is an inhibitor of the cytochrome P450 (CYP) isoform CYP2C8 (IC50 = 4.1 µM). It is taken up by organic anion transporting polypeptide 1B1 (OATP1B1) in sandwich cultured human hepatocytes (SCHHs) and inhibits cellular uptake of valsartan in MDCK cells expressing OATP1B1 (IC50 = 20.4 µM).
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