Gemfibrozil 1-O-β-Glucuronide |
| カタログ番号GC43743 |
ゲムフィブロジル 1-O-β-ゲムフィブロジルの代謝産物であるグルクロニドは、強力で競合的な P450 (CYP) アイソフォーム CYP2C8 阻害剤であり、IC50 は 4.07 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 91683-38-4
Sample solution is provided at 25 µL, 10mM.
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Gemfibrozil 1-O-β-glucuronide is a major metabolite of gemfibrozil that is formed when gemfibrozil undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7. Gemfibrozil 1-O-β-glucuronide is an inhibitor of the cytochrome P450 (CYP) isoform CYP2C8 (IC50 = 4.1 µM). It is taken up by organic anion transporting polypeptide 1B1 (OATP1B1) in sandwich cultured human hepatocytes (SCHHs) and inhibits cellular uptake of valsartan in MDCK cells expressing OATP1B1 (IC50 = 20.4 µM).
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