Gemfibrozil 1-O-β-Glucuronide |
| Catalog No.GC43743 |
Gemfibrozil 1-O-β-Glucuronide, un métabolite du Gemfibrozil, est un inhibiteur puissant et compétitif de l'isoforme CYP2C8 du P450 (CYP) avec une IC50 de 4,07 μM.
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Cas No.: 91683-38-4
Sample solution is provided at 25 µL, 10mM.
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Gemfibrozil 1-O-β-glucuronide is a major metabolite of gemfibrozil that is formed when gemfibrozil undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7. Gemfibrozil 1-O-β-glucuronide is an inhibitor of the cytochrome P450 (CYP) isoform CYP2C8 (IC50 = 4.1 µM). It is taken up by organic anion transporting polypeptide 1B1 (OATP1B1) in sandwich cultured human hepatocytes (SCHHs) and inhibits cellular uptake of valsartan in MDCK cells expressing OATP1B1 (IC50 = 20.4 µM).
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