GSK3 Inhibitor XIII (Synonyms: Glycogen Synthase Kinase 3 Inhibitor XIII) |
| Catalog No.GC43790 |
GSK3 Inhibitor XIII es un inhibidor de GSK-3 potente y competitivo con ATP con una Ki de 24 nM.
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Cas No.: 404828-08-6
Sample solution is provided at 25 µL, 10mM.
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GSK3 Inhibitor XIII is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 µM. It inhibits androgen receptor transactivation in 22Rv1, LNCaP, and LNCaP-SSR cell lines in a dose-dependent manner. It promotes nuclear export of the androgen receptor and decreases translocation to the nucleus in PC3 and PCa prostate cancer cells, respectively. In HEK293 cells expressing the rat Nav1.2 channel, pretreatment with GSK3 inhibitor XIII dose-dependently potentiates peak current densities.
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