HJC 0416 hydrochloride |
| Catalog No.GC50343 |
El clorhidrato de HJC 0416 es un inhibidor de STAT3 potente y activo por vía oral con un perfil anticancerígeno mejorado que Stattic. El clorhidrato de HJC 0416 es un agente anticancerígeno prometedor para el estudio del cáncer de mama.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2415263-08-8
Sample solution is provided at 25 µL, 10mM.
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STAT3 inhibitor. Downregulates phosphorylation of STAT3 and increases the expression of cleaved caspase-3. Inhibits cell-cycle progression and proliferation in breast and pancreatic cancer cells in vitro (IC50 values are in the range 0.04 - 1.97 μM). Also inhibits growth of ER-negative breast cancer xenografts in mice. Orally bioavailable.
Chen et al (2014) Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur.J.Med.Chem. 82 195 PMID:24904966
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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