HJC 0416 hydrochloride |
| Katalog-Nr.GC50343 |
HJC 0416 Hydrochlorid ist ein potenter und oral aktiver STAT3-Hemmer mit einem verbesserten Antikrebsprofil als Static. HJC 0416 Hydrochlorid ist ein vielversprechendes Antikrebsmittel für Brustkrebsstudien.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2415263-08-8
Sample solution is provided at 25 µL, 10mM.
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STAT3 inhibitor. Downregulates phosphorylation of STAT3 and increases the expression of cleaved caspase-3. Inhibits cell-cycle progression and proliferation in breast and pancreatic cancer cells in vitro (IC50 values are in the range 0.04 - 1.97 μM). Also inhibits growth of ER-negative breast cancer xenografts in mice. Orally bioavailable.
Chen et al (2014) Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur.J.Med.Chem. 82 195 PMID:24904966
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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