Lagosin (Synonyms: Antibiotic A 246,14-hydroxy Filipin,NSC 105388,NSC 276732) |
Catalog No.GC11791
One-Click Copy Product Info
|
Lagosin (Fungichromin) es un antibiÓtico macrÓlido de polieno. Lagosin ha demostrado actividad antifÚngica de amplio espectro y es inmune a la resistencia a los medicamentos.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 6834-98-6
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
Lagosin is a polyene macrolide antibiotic. Lagosin exerts its antifungal effects by interacting with membrane sterols and possesses broad-spectrum antifungal and antitumor activities. Lagosin can be used in research related to antifungal infections and antitumor studies[1-4].
In vitro, Lagosin (1-2μg/ml) was used to treat Chinese hamster V79 cells for 2 hours, followed by stimulation with [14C]bleomycin A2. Lagosin significantly enhanced the cellular uptake of [14C]bleomycin A2[5]. Lagosin (50μg/ml) was used to treat L-form cells of Escherichia coli W1655F+ for 6 hours. Lagosin inhibited the growth of the L-form cells[6].
In vivo, Lagosin (20mg/kg; single injection) was administered via intraperitoneal injection to Balb/C mice bearing EMT6 solid tumors. Lagosin alone did not exhibit significant cytotoxicity against the tumor cells[6].
References:
[1] Dembitsky VM, Terent'ev AO, Baranin SV, et al. Boron's Double Edge-Antibiotics, Toxins, and the Fine Line Between Them. Molecules. 2026 Mar 18;31(6):1021.
[2] Peng C, An D, Ding WX, et al. Fungichromin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum. Appl Microbiol Biotechnol. 2020 Dec;104(24):10437-10449.
[3] Pandey RC, Guenther EC, Aszalos AA, et al. Physicochemical and biological comparison of polyene macrolide antibiotics fungichromin, lagosin and cogomycin. J Antibiot (Tokyo). 1982 Aug;35(8):988-96.
[4] Arora HR. Effects of polyene antibiotics on the heart. A study with nystatin and lagosin. Med Pharmacol Exp Int J Exp Med. 1965;13(3):155-60.
[5] Akiyama SI, Hidaka K, Komiyama S, et al. Control of permeation of bleomycin A2 by polyene antibiotics in cultured Chinese hamster cells. Cancer Res. 1979 Dec;39(12):5150-4.
[6] Twentyman PR. The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo. Br J Cancer. 1976 Apr;33(4):459-64.
| Cell experiment [1]: | |
Cell lines | Chinese hamster V79 cells |
Preparation Method | Chinese hamster V79 cells were maintained in minimal essential medium supplemented with 10% fetal bovine serum. Cells were treated with Lagosin and bleomycin A2 for specified durations. |
Reaction Conditions | 4-12μg/ml; 2h pretreatment |
Applications | Lagosin significantly enhanced the cellular uptake of [14C]bleomycin A2 by 2- to 4-fold. Lagosin synergistically inhibited DNA synthesis and colony-forming activity when combined with bleomycin A2. |
| Animal experiment [2]: | |
Animal models | Balb/C mice bearing EMT6 solid tumours |
Preparation Method | Lagosin was suspended in 0.5% carboxymethyl cellulose in Hanks' solution and injected intraperitoneally (i.p.). Tumours were treated when they reached a size of around 150mm³ (Day 9-10 post-inoculation). |
Dosage form | 20mg/kg; i.p.; single injection |
Applications | Lagosin alone was not very cytotoxic to the tumour cells in vivo. |
References: | |
| Cas No. | 6834-98-6 | SDF | |
| Sinónimos | Antibiotic A 246,14-hydroxy Filipin,NSC 105388,NSC 276732 | ||
| Chemical Name | (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one | ||
| Canonical SMILES | C/C1=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC([C@@]([C@H](O)CCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)[C@@H](O)[C@@H]1O)=O | ||
| Formula | C35H58O12 | M.Wt | 670.8 |
| Solubility | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.4908 mL | 7.4538 mL | 14.9076 mL |
| 5 mM | 298.2 μL | 1.4908 mL | 2.9815 mL |
| 10 mM | 149.1 μL | 745.4 μL | 1.4908 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >96.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)